Physical and Genomic Abnormalities in Lung Cancer

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Submitted by Trudy Oliver of the Jacks Laboratory at the Koch Institute

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Trudy Oliver
Jacks Laboratory, Koch Institute for Integrative Cancer Research at MIT
MicroCT Imaging and Super-Resolution Fluorescence Microscopy

"The image depicts mouse lungs developing tumors based on mutations frequently observed in human cancer.  The inset depicts a lung cancer cell derived from these tumors and cultured in vitro.  This cell provides a dramatic illustration of severely abnormal cell division and genomic instability in lung cancer.  At the same time, this genomic instability highlights a window of opportunity for therapeutic intervention by targeting the DNA damage repair pathways in which tumors are critically dependent."