Submitted by Trudy Oliver of the Jacks Laboratory at the Koch Institute
Jacks Laboratory, Koch Institute for Integrative Cancer Research at MIT
MicroCT Imaging and Super-Resolution Fluorescence Microscopy
"The image depicts mouse lungs developing tumors based on mutations frequently observed in human cancer. The inset depicts a lung cancer cell derived from these tumors and cultured in vitro. This cell provides a dramatic illustration of severely abnormal cell division and genomic instability in lung cancer. At the same time, this genomic instability highlights a window of opportunity for therapeutic intervention by targeting the DNA damage repair pathways in which tumors are critically dependent."