Nanoparticle Trafficking Inside a Cell

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Submitted by Gaurav Sahay, Christopher Alabi, Robert Langer and Daniel Anderson of the Langer and Anderson Labs at the Koch Institute

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Gaurav Sahay, Christopher Alabi, Robert Langer, Daniel Anderson
Langer and Anderson Laboratories, Koch Institute for Integrative Cancer Research at MIT
Spinning-Disk Confocal Micrograph

"This image shows microtubule assisted endocytic trafficking of nanoparticles carrying siRNA.  Microtubules serve as a platform to internalize a nanoparticle that encapsulates two differently labeled siRNA. The co-localization indicates that the nanomaterial may be still intact and had has yet to release the siRNA (s) into the cellular milieu."