Cellular Uptake of siRNA-Carrying Nanoparticles

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Submitted by Gaurav Sahay, Christopher Alabi, Robert Langer and Daniel Anderson of the Langer and Anderson Labs at the Koch Institute

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Gaurav Sahay, Christopher Alabi, Robert Langer, Daniel Anderson
Langer and Anderson Laboratories, Koch Institute for Integrative Cancer Research at MIT
Spinning-Disk Confocal Micrograph

"This image shows nanoparticles that encapsulate two distinctly labeled small interfering RNA molecules (red and green).  The cell internalizes the nanoparticles utilizing endocytic trafficking. The co-localization indicates that the nanomaterial may be still intact and had has yet to release the siRNA (s) into the cellular milieu."