Cellular Uptake of siRNA-Carrying Nanoparticles


Submitted by Gaurav Sahay, Christopher Alabi, Robert Langer and Daniel Anderson of the Langer and Anderson Labs at the Koch Institute


Gaurav Sahay, Christopher Alabi, Robert Langer, Daniel Anderson
Langer and Anderson Laboratories, Koch Institute for Integrative Cancer Research at MIT
Spinning-Disk Confocal Micrograph

"This image shows nanoparticles that encapsulate two distinctly labeled small interfering RNA molecules (red and green).  The cell internalizes the nanoparticles utilizing endocytic trafficking. The co-localization indicates that the nanomaterial may be still intact and had has yet to release the siRNA (s) into the cellular milieu."