DNA Repair by the Protein AAG

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Submitted by Jeremy W. Setser and Catherine L. Drennan of the Drennan Laboratory in the Department of Chemistry

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Jeremy W. Setser, Catherine L. Drennan
Drennan Laboratory, Department of Chemistry (in collaboration with Samson Laboratory, Department of Biological Engineering)
X-Ray Crystallographic Data and Adobe Illustrator

"Alkyladenine DNA glycosylase (AAG) is a DNA repair protein responsible for the removal of harmful lesion bases brought about by various carcinogens and oxidative stress. By observing this protein in complex with DNA on the atomic level, we can better understand its mechanism of action and thus, better understand its role in DNA repair.  In this image, AAG (blue) is shown in complex with a 13-mer double-stranded DNA oligonucleotide (orange)."