Therapeutic Cells Loaded with Synthetic Particles, Version #3

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Submitted by Matthias T. Stephan, James J. Moon, Soong Ho Um, Anna Bershteyn and Darrell J. Irvine of the Irvine Laboratory at the Koch Institute for Integrative Cancer Research at MIT

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Matthias T. Stephan, James J. Moon, Soong Ho Um, Anna Bershteyn, Darrell J. Irvine 
Irvine Laboratory, Koch Institute for Integrative Cancer Research
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"We devised a facile and generalizable strategy to robustly augment existing cell therapies, such as infusions of tumor-reactive or bone marrow transplantation. By chemically conjugating submicron-sized drug/growth factor-loaded synthetic particles directly onto the plasma membrane of donor cells prior to infusion into the patient, therapeutic cells are “armed” with a continuous source of stimulants which greatly enhances their survival, proliferation and therapeutic functionality."