Poly(ADP-ribose) at Mitotic Spindle Poles

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Submitted by Sejal Vyas of the Chang Laboratory at the Koch Institute

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Sejal Vyas
Chang Laboratory, Koch Institute for Integrative Cancer Research at MIT
Spinning-Disk Confocal Micrograph

"The goal of our research is to understand the functions of the polymeric protein modification poly(ADP-ribose) -- or pADPr -- on various aspects of cell biology such as cell division and stress responses.  This image shows enrichment of pADPr at spindle poles using a novel reagent.  pADPr is required for mitotic spindle formation."