How Do Macrophages Contribute to Tissue Remodeling?


Submitted by David Kling of the Genomic Sequencing and Analysis Group at the Broad Institute


The goal of this work is to define how macrophages contribute to tissue remodeling during the lung branching morphogenesis phase of fetal lung development and how anti-inflammatory molecules can potentially alter this process. This image, taken using a combination of fluorescent and darkfield microscopy, shows rat fetal lungs stained with a fluorescent dye that stains predominantly cell vacuoles involved in breaking down macromolecules. We were trying to determine the where tissue remodeling was taking place and if macrophages were involved.