Visualizing the Blueprint of DNA Damaging in Ovarian Cancer by Therapeutic Agents 3

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Submitted by Lawrence Mensah and Paula Hammond of the Koch Institute for Integrative Cancer Research at MIT

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The current treatment for ovarian cancer is the use of potent DNA damaging agent, Cisplatin as a monotherapy. Recently PARP inhibitors have been developed, but also used as a monotherapy for a number of solid tumors. The goal of my research is to test the combination of Cisplatin and PARP inhibitor to induce ‘synthetic lethality’ for ovarian cancer treatment.