Submitted by Steffen Rickelt of the Hynes Laboratory at the Koch Institute for Integrative Cancer Research
This image shows a cross section through villi of the mouse small intestine. Stained are cell nuclei (red) located to the base of nutrient-absorbing and mucus-secreting columnar epithelial cells (brown) that surround the cellular connective tissue forming the core of each villus.
I primarily took this image for documentation purpose of antibodies against the well-known intestinal marker proteins CDX2 and Pan-Keratin. With this approach I aim to setup multiple immunohistochemical-stainings in our laboratory for their future application on a larger number of human colorectal cancer patient samples.