Lamellipodia Protrusion and Cell Migration 2

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Guillaume Carmona

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This picture shows a mouse embryonic fibroblasts cell. This cell has been stimulated with a growth factor that activates a signaling pathway leading to lamellipodia protrusion (the protrusion of the cell membrane at the front of the cell is one of the first step in cell motility). The actin cytoskeleton (a critical component of the skeleton of the cell that drive cell migration) is labeled in green and Lamellipodin, an actin-regulatory protein, is labelled in red. We are trying to understanding the mechanisms that allow a cancer cell to migrate, invade and metastasize, which is a fundamental problem in the development of effective cures against metastatic carcinomas.