Immune Attack: Implantable Devices for Drug Delivery 1

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Joshua C. Doloff, Shady Farah, Atieh Sadraei, Daniel G. Anderson and Robert Langer

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Our research focuses on improved drug delivery technologies to improve biomedical treatments used in different disease models and clinical applications. In general, implanted devices and transplanted organs/tissues instigate severe rejection responses, including inflammation, immune attack, fibrosis, and scarring, resulting in loss of device function and therapeutic failure. This image shows an organized and concerted multi-cellular arm reaching out to grab and scar over one of our implanted biomaterial devices.