Immune Attack: Implantable Devices for Drug Delivery 1


Joshua C. Doloff, Shady Farah, Atieh Sadraei, Daniel G. Anderson and Robert Langer


Our research focuses on improved drug delivery technologies to improve biomedical treatments used in different disease models and clinical applications. In general, implanted devices and transplanted organs/tissues instigate severe rejection responses, including inflammation, immune attack, fibrosis, and scarring, resulting in loss of device function and therapeutic failure. This image shows an organized and concerted multi-cellular arm reaching out to grab and scar over one of our implanted biomaterial devices.