Microfluidics and Cell Lineage

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Robert Kimmerling, Scott Knudsen, Scott Manalis

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This is a portion of a larger array designed to trap and observe many individual cells as they grow and divide. Fluid flowing through the array is modelled in color, and causes each newly-divided cell to be deposited in the next available position. By holding cells in place, the identity of each cell in the array can be known, and a family tree can be created when the array is full. The structure of the array also allows cells to be released one at a time, so they are available for modern single-cell analytical methods, whose results can be linked with their lineage.