Morphological and Proliferative Changes in the Brain

Alzheimer’s disease (AD) model mice are stimulated with non-invasive 40-Hz auditory flicker (Gamma ENtrainment Using Sensory stimulus, or GENUS), which has been shown to reduce extracellular aggregates of amyloid beta peptides, a hallmark of AD pathology, and elicit a glial response. Here, blood vessels (green) and reactive astrocytes (magenta), cells crucial for synaptic function and maintaining blood brain barrier, are shown in the hippocampus (blue: DAPI, neuronal cell body layer in CA1 region of hippocampus) after GENUS.