Enzyme Activity for Computational Drug Design

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David A. Bloore, Tidor Group

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This is an image of an enzyme that cancer cells use to suppress the immune system. It is Protein DataBase entry 5ETW. I am trying to use publicly available data to determine the structure of the active site of this enzyme, and this is one of the crystal structures of IDO-1 bound with an inhibitor. If I can confidently determine the structure of the active site then I can start to design a new cancer drug that targets it.

Keywords: 2018, CSAIL, Department of Biological Engineering, data visualization, structural biology, MIT

Collection: Image Awards 2018