Visualizing Tumor Heterogeneity 3

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Leah Caplan, Jatin Roper, Inbal Avraham-Davidi, Sebastian Santos, Aviv Regev, Omer Yilmaz

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These images depict a snapshot of a growing mouse colon tumor at the cellular level. This project takes advantage of our expertise in mouse modeling of cancer (Yilmaz lab) and single cell sequencing (Regev Lab). First, we performed genome-wide sequencing of individual cells within colon cancers. We analyzed these data to identify a group of cells that are Lgr5+ cancer stem cells. Then, to visually study these cells in the context of the whole tumor, we performed imaging of these cells at the single cell level.