Nested Stochastic Block Model

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Alexander LeNail

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This image is a visualization of the results of an algorithm seeking to “disentangle” the protein-protein interaction network released a couple months ago by the Lage lab at the Broad (named “InWeb_InBioMap”). The goal of the algorithm is to understand the organization principles of the proteome, and by extension, human biology. Using the protein communities discovered by the algorithm, we can infer the existence of functional modules and complexes – systems of proteins acting in exquisite concert. I made this picture to visualize the output of my algorithm, to get a first peek at what it had discovered. I then went through and rigorously analyzed the results.