Mitotic Catastrophe: Death of the Cancer Cells

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Submitted by Fred Lam of the Floyd Lab in the Koch Institute for Integrative Cancer Research at MIT

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This is a picture of the nuclei of three cancer cells that are undergoing rapid cell death caused by damage to their DNA following treatment with a novel anticancer drug. I took this image to try to elucidate the mechanism(s) behind the antitumorigenic properties of a novel small molecule we are using to treat different types of cancers. Understanding the mechanism(s) through which this small molecule is triggering cell death in cancer cells will allow us to combine this drug with other small molecule inhibitors to increase treatment efficacy of a variety of cancers.