Submitted by Carman Man Chung Li of the Jacks Lab at the Koch Institute
Carman Man Chung Li
Jacks Lab, Koch Institute
Epi-Fluorescence Micrograph
"These images show that cancer cells can behave differently in terms of their ability to degrade their surrounding tissues. In these images, invasive (right) and non-invasive (left) lung cancer cells are cultured on a green fluorescently labeled extracellular matrix, but only the invasive cells are able to degrade the matrix, leaving behind focal black patches. I was very excited when I first saw these images with my eyes through the microscope, as I was starting my project as a new graduate student in the lab. The difference between the invasive and non-invasive cells is dramatic. I am currently studying the molecular mechanism that differentiates the invasiveness of these cells."
Keywords: 2012, Jacks Laboratory, epi-fluorescence microscopy, cancer cells, extracellular matrix
Collection: Image Awards 2012