Live Neurons Labeled with a Genetically Encoded Fluorescent Protein

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Submitted by Jason Coleman of the Bear Lab in the Picower Institute for Learning and Memory

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Jason Coleman
Bear Lab, Picower Institute for Learning and Memory
Multiphoton Micrograph

"This image shows neurons in a volume of visual cortex of a living mouse labeled with a genetically encoded fluorescent protein. Different colors correspond to portions of axon branches in different depths of a 3D volume.  We took this image to monitor the structure of neurons in a living mouse brain.  This technique allows us to illuminate a handful of neurons with exquisite detail to understand whether or how experience can modify the structure of circuits in the brain that may be important for learning and memory and implicated in disease."