Visualizing Inhibitory Neurons with Immunofluorescence

Submitted by Eitan Kaplan of the Bear Lab at the Picower Institute for Learning and Memory

Eitan Kaplan
Bear Lab, Picower Institute for Learning and Memory
Confocal Micrograph

"In this image we used immunofluorescence imaging to visualize a class of nerve cells called parvalbumin-positive inhibitory neurons.  Changes in the number of this neuron type has been implicated in many neurological diseases including schizophrenia.  To understand their influence, we need to  be able to visualize this specific class of inhibitory neurons."