A Breast Cancer Cell Extends its Cytoskeleton

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Submitted by Brett Zani of the Edelman Lab in the Harvard-MIT Division of Health Sciences and Technology

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Brett Zani
Edelman Lab, Harvard-MIT Division of Health Sciences and Technology
Epi-Fluorescence Micrograph

"A cell from a human breast carcinoma grows over the top of primary human aortic endothelial cells. The tubulin cytoskeleton (green) surrounds the nucleus (blue) of the cancerous cell and extends out to connect with other cells of the breast carcinoma (outside of the field of view) by moving over the underlying endothelial cells (best identified by the red F-actin cytoskeleton). Growing these two cell types together promotes the unique cellular morphology (e.g. long cellular extensions) of the breast cancer cells, which is typically not seen when these cancerous cells are cultured alone."