Breast Cancer Cells Invade the Lung

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Submitted by Tsukasa Shibue in the Weinberg Laboratory at the Whitehead Institute

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Tsukasa Shibue
Weinberg Laboratory, Whitehead Institute
Deconvolution Microscopy

"I am studying the cell-biological behavior of cancer cells after metastatic dissemination into foreign tissues. Aggressive mouse mammary carcinoma cells (D2A1) were engineered to express a fluorescent fusion protein containing integrin alpha5 (green). These cells were injected into mice through the tail-vein and allowed to disseminate within the lung tissue. The formation of abundant, integrin alpha5-containing plaques indicated that the D2A1 cells can interact with the extracellular matrix components of the lung parenchyma in a way enabling the activation of adhesion-associated signaling events."