Breast Cancer Cells Invade the Lung


Submitted by Tsukasa Shibue in the Weinberg Laboratory at the Whitehead Institute


Tsukasa Shibue
Weinberg Laboratory, Whitehead Institute
Deconvolution Microscopy

"I am studying the cell-biological behavior of cancer cells after metastatic dissemination into foreign tissues. Aggressive mouse mammary carcinoma cells (D2A1) were engineered to express a fluorescent fusion protein containing integrin alpha5 (green). These cells were injected into mice through the tail-vein and allowed to disseminate within the lung tissue. The formation of abundant, integrin alpha5-containing plaques indicated that the D2A1 cells can interact with the extracellular matrix components of the lung parenchyma in a way enabling the activation of adhesion-associated signaling events."