Submitted by Sangeeta Bhatia and Kelly Stevens at the Koch Institute
Sangeeta Bhatia, Kelly Stevens
Laboratory for Multiregenerative Technologies, Koch Institute
"To build engineered tissues that will ultimately be useful as implantable human therapies (i.e., for organ repair or replacement) we must have complete understanding of the ‘design specifications’ on how tissues are (in the body) and can be constructed so that they are most functional.
We used microfabrication technologies to pattern several types of cells (endothelial cells, green; fibroblasts, red) in a three-dimensional engineered tissue. We are trying to understand how different cell types communicate with one another as they come together to form tissues. By developing technologies to alter spatial relationships and organization between the different cell types we can study how organization impacts cell behavior and tissue function."