Engineered Vessels Deliver Blood to Hepacytes

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Submitted by Sangeeta Bhatia and Kelly Stevens at the Koch Institute

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Sangeeta Bhatia, Kelly Stevens
Laboratory for Multiregenerative Technologies, Koch Institute
Confocal Microscopy

"We aim to build engineered tissues that will ultimately be useful as implantable human therapies (i.e., for organ repair or replacement).  A major challenge is to successfully engineer a blood supply for the engineered tissues. We created engineered liver tissue containing hepatocytes (liver cells) and engineered blood vessels and implanted them into mice. Here, hepatocytes (green) are shown next to red blood cells (red) from the mouse, showing that our engineered blood vessels connected with mouse blood vessels and delivered blood to the hepatocytes."