Effect of Alternative Splicing on Blood Flow

Effect of Alternative Splicing on Blood Flow

Submitted by Patrick Murphy in the Hynes Lab at the Koch Institute

MIT Department of Biology, Koch Institute at MIT

Alternative splicing of genes results in multiple proteins from the same gene sequence in the DNA. We aim to understand the regulation and function of alternative splicing of Fibronectin and other genes in the vascular response to damaging types of blood flow. This image shows the extracellular fibrillar matrix produced by the endothelial cells which line blood vessels under flow, as revealed by immunofluorescent staining.

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