Effect of Alternative Splicing on Blood Flow


Submitted by Patrick Murphy in the Hynes Lab at the Koch Institute


Alternative splicing of genes results in multiple proteins from the same gene sequence in the DNA. We aim to understand the regulation and function of alternative splicing of Fibronectin and other genes in the vascular response to damaging types of blood flow. This image shows the extracellular fibrillar matrix produced by the endothelial cells which line blood vessels under flow, as revealed by immunofluorescent staining.