Cellular Adhesion on a Microarray


Submitted by Nathan E. Reticker-Flynn of the Bhatia Lab at the Koch Institute


"Extracellular matrix (ECM) molecules are a family of molecules that fill the space around cells. During cancer progression, interactions between cells and their surrounding ECM are perturbed in a manner that permits invasion and metastasis. To understand this process better, we engineered a microarray technology that allows us to query interactions between cells and hundreds of unique combinations of ECM molecules. This image depicts cells adhered to a single island of one ECM combination."