Extracellular Matrix: Microarray Views

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Submitted by Nathan E. Reticker-Flynn and David F. Braga Malta of the Bhatia Lab at the Koch Institute

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"Extracellular matrix (ECM) molecules are a family of molecules that fill the space around cells. During cancer progression, interactions between cells and their surrounding ECM are perturbed in a manner that permits invasion and metastasis. To understand this process better, we engineered a microarray technology that allows us to query interactions between cells and hundreds of unique combinations of ECM molecules. This image depicts the ECM microarray stained for all of the different ECM combinations, presented as small islands, present on the arrays."