Exploring the Effects of Immunotherapy Against Neurodegeneration 2

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side by side comparison of brain structures with fluorescent tags

Nader Morshed, Leyla Akay, Li-Huei Tsai, Forest White

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side by side comparison of brain structures with fluorescent tags

Seen here is a side by side comparison showing microglia in their resting state (right) compared with microglia in a mouse undergoing neurodegeneration (left). This image was taken as part of an analysis of how a particular immune receptor affects microglial inflammation. We were evaluating whether an inhibitor of this receptor could cross into the brain and affect its function in vivo.

This project has aimed to take technologies refined in the Koch Institute to study glioblastoma and use them to develop new therapies against Alzheimer’s disease. We hope to understand how immunotherapies targeted against cancer may also affect the progression of dementia.