Calling the Shots: A Flexible Platform for All-in-One Delivery

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glowing pink cube-like capsules on a glass slide

Morteza Sarmadi, Christina Ta, Robert Langer, Ana Jaklenec

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glowing pink cube-like capsules on a glass slide

Morteza Sarmadi, Christina Ta, Robert Langer, Ana Jaklenec
Koch Institute at MIT

Offering local delivery once every three days for up to six months, these hollow microparticles could really pack a punch against cancer.

The Jaklenec group in the Langer Lab is modifying the microfabricated capsules—originally created as a single-shot vaccine delivery system—to accommodate the co-delivery of chemotherapy with other treatment approaches such as immunotherapy or gene therapy.

They took the image to understand the mechanism behind the cargo’s release. The pink color comes from the red dye being used as a proxy for the combination of interest.