Neuronal Soma Receive Information from Neighboring Neurons

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Submitted by Miquel Bosch of the Bear Lab at the Picower Institute for Learning and Memory

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Miquel Bosch
Bear Lab, Picower Institute for Learning and Memory
Two-Photon Micrograph

"This is a two-photon microscopy image of a live neuron from an organotypic rat hippocampal slice culture transfected with PSD-95-mCherry to visualize sites of postsynaptic contacts.  Each bright puncta is an excitatory synapse.  We were testing a virus designed to infect neurons to express PSD-95-mCherry, which will show us the position of the excitatory synapses. Our goal was to inject this virus in the rat brain and perform in vivo two-photon live imaging of the evolution of synaptic contacts during experience-driven morphological changes in the visual cortex network.

Our larger goal is to unravel the molecular mechanisms of learning and memory at the most fundamental level: the individual synapse."