Huntingtin Protein Expression in Fly Neurons

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Submitted by J. Troy Littleton of the Picower Institute for Learning and Memory

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J. Troy Littleton
Picower Institute for Learning and Memory
Confocal Micrograph

"This image shows Drosophila cultured neurons expressing membrane-tethered GFP (green) and the human Huntingtin protein (red). 

Joost Schulte, a post-doc in my lab, was looking for drugs that reduce neurotoxicity in the neurodegenerative disorder, Huntington’s Disease. An expansion of a polyglutamine stretch within the Huntingtin protein causes it to misfold and damage neurons."