Tissue Remodeing After a Transplant

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This image, captured by Omid Veiseh, Joshua Doloff, Minglin Ma, Alan Chiu, Arturo Vegas, and Daniel G. Anderson, shows the tissue remodeling that occurs after transplant of biomaterials into mice.

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Omid Veiseh, Joshua Doloff, Minglin Ma, Alan Chiu, Arturo Vegas and Daniel G. Anderson
Anderson and Langer Laboratories, Koch Institute

"The image shows the tissue remodeling that occurs after transplant of biomaterials into mice. Here we have transplanted a hydrogel material that is developed for pancreatic islet cell transplantation as therapy for diabetes. The green and red in the image show the different types of cells that are involved with tissue remodeling around a transplanted material.

A better understanding of the key cells involved in the response transplanted materials can help better guide us in developing new more compatible biomaterials for transplantations.  Our aim is to develop new materials that do not invoke an immunological response but yet can integrate in to the body and perform their function."