T cell Quorum Crowd

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Submitted by Sudha Kumari of the Irvine Laboratory at the Koch Institute

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T cells are the important cells for generating proper immune response. For a coordinated response, they talk to each other, but only very briefly, and this process has been extremely difficult to catch because T cell contacts are very short lived. Using an artificial platform (red dots), human blood T cells are forced to form a stable bunch (each cell represented in different color) to be able to interrogate and understand how they communicate with each other during immune response. The image presents a tool to pursue my aim of studying T cell-T cell contacts.