Vascularized Pancreas Organoid

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Haiting Ma, Jaenisch Lab

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This image was taken to assess the vasculature network of in vitro cultured human pancreatic islet cells. It shows an in vitro culture of a vascularized pancreas organoid stained with an anti-PDX1 antibody (red), an anti-CD31 antibody (green), and DAPI (blue). Proper vascularization is critical for the function of pancreatic islet, and this picture suggests that equipping pancreatic organoids with vasculature is potential possible before in vivo therapeutic applications.