Immunogenic Drugs Infiltrate Lung Tumors 1

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Steffen Rickelt, Christina Pfirschke

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Recent clinical studies have demonstrated that it is possible to fight cancer not only by targeting cancer cells directly, but also by manipulating normal immune cells such as T cells that infiltrate tumors. Most notably, immunotherapies that use drugs called ‘immune checkpoint inhibitors’ can successfully activate patient’s own T cells to kill tumors.

The presented image shows a section through a tumor-bearing lung lobe of a mouse that received immunogenic drugs. In the center of the image, a lung cancer tumor nodule is shown, with tumor cells highlighted by nuclear staining (red), surrounded and permeated by a vasculature meshwork (brown).