Pushing Boundaries: Ovarian Cancer Hides in Plain Sight

Look

Erik C. Dreaden, Yi Wen Kong, Michael Yaffe, Paula T. Hammond

Here, we see an ovarian tumor that has invaded the abdominal wall (peritoneum), a common site of metastatic spread.

Read

Erik C. Dreaden, Yi Wen Kong, Michael Yaffe, Paula T. Hammond
Koch Institute at MIT

Persistence is key. Here, an ovarian tumor clings to the abdominal wall, slowly breaking through the tissue boundaries that block its metastatic spread. The tissues here were stained with a molecule that binds to cells that are rapidly growing and multiplying (colored white).

Just as tenacious as these proliferating cells, however, are the researchers who study it. The Hammond and Yaffe Labs are working together to better understand and exploit the genetic weaknesses of these tumors in various disease models, and soon will test their response to experimental treatments, unlocking new avenues for investigation and intervention.

Watch

Erik Dreaden shares the story and science behind his award-winning image. You can also watch the presentation from the exhibition opening event on March 23, 2017 here.